Shu Zhu, PhD

Postdoctoral Associate

Departments & Organizations

Flavell Lab Members

Biography

I got my BS degree (2006) in biology in University of Science and Technology of China (4th in China according to US news 2017), then got my PhD degree (2012) in immunology in Chinese Academy of Sciences (1st in China according to Nature Index 2016). I joined Richard Flavell’s lab as a postdoctoral associate in 2012. My research focuses on the host/pathogen/symbiote interface, paying particular attention most recently to the interaction between enteric virus and Nod-like receptors (NLRs) mediated host immune response in context of infectious and inflammatory diseases. As PI on a fellowship co-funded by Helen Hay Whitney Foundation and HHMI, I studied the virus-NLRs interaction as well as Microbiota-T cell interaction in the intestine, to elucidate how immune systems including Nod-like receptors and T cells sense microorganisms or their products in intestine; and to determine how microorganisms including enteric viruses evade the immune system and further contribute to infectious and inflammatory diseases. My recent works identified for the first time that, two Nod-like receptors (Nlrp6 and a novel NLR, Nlrp9), which are specifically expressed in intestinal, are critical for anti-enteric virus response (Wang, Zhu et al., Science. 2015; Zhu et al., Nature, 2017). In addition, I successfully collaborated with other researchers, working on T cell epigenetics (Li, Tong, Zhu et al., Nature, 2017), tumor immunology (Pan, Zhu et al., Immunity, 2017), innate sensing of DNA damage, as well as CRISPR screening, and produced several peer-reviewed publications from each project (see my CV).

Education & Training

PhD Chinese Academy of Sciences, P.R.C. (2012)

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