My phD research started with the study of thyroid organogenesis, in particular the mechanisms upstream the specification of the thyroid primordium.
The importance of the thyroid as an endocrine organ and a major player in regulating metabolism drew my attention towards this field and towards the inner mechanisms regulating metabolic dysfunction.
I then joined Vishwa Deep Dixit lab as a post-doc associate in 2013, my research here is focused on unraveling the immune-metabolic interactions taking place during aging-associated chronic diseases and metabolic dysfunctions.
I have demonstrated that the ablation of the GH-IGF1 somatotropic axis, with the deletion of GH-R signaling, protects against the sterile inflammatory cascade through inhibition of the NLRP3 Inflammasome complex in aging.
Also, myeloid-specific ablation of the IGF1R signaling alters the host adaption to diet-induced obesity exacerbating the metabolic dysfunction through a reduction of adipose specific M2-like signatures.
My future goal is to understand how caloric restriction impacts immune-metabolic interactions by alteration of specific gene signatures and metabolite availability, leading to mechanisms dictating healthy aging.
Education & Training
|PhD||University of Naples, Italy (2013)|
|BS||University of Naples, Italy (2007)|