Joseph Edgar Craft, MD

Paul B. Beeson Professor of Medicine (Rheumatology) and Professor of Immunobiology; Section Chief, Rheumatology; Program Director, Investigative Medicine; Paul B. Beeson Professor of Medicine

Research Interests

Antigens, Differentiation, T-Lymphocyte; Autoimmune Diseases; Biology; Immunity; Lupus Erythematosus, Systemic; Investigative Techniques; Rheumatology; Cytokines

Research Organizations

Internal Medicine: Rheumatology: Rheumatic Diseases Research Core

Immunobiology: HTI

Faculty Research

Immunology and Immunotherapy

Yale Cancer Center: Cancer Immunology

Office of Cooperative Research

Research Summary

We have a longstanding interest in dissecting the pathogenesis of systemic autoimmunity, focusing upon the activation and differentiation of CD4 T effector cell subsets in mice and in humans. Our lab has characterized CD4 T cells that help B cells in murine models of lupus and in conventional immune responses, with the idea that information gleaned from the latter studies could be applied to our understanding of autoimmunity. In recent work, we have begun to define the transcription factors critical for the development and function of CD4 T cells that help B cells, with ongoing studies aimed at further investigating these cells developmentally, and dissecting the mechanisms that lead to their effector function in autoimmunity and inflammation.

Specialized Terms: Autoimmunity; Cytokines; Lupus; T Cell Differentiation; Tolerance

Extensive Research Description

Ongoing studies are targeted towards identification of the developmental pathways of CD4 T cells that provide B cell help and that promote inflammation, and dissection of their potential to promote autoimmunity and inflammation.

Selected Publications

Full List of PubMed Publications

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Contact Info

Joseph Edgar Craft, MD
Mailing Address
PO Box 208031
300 Cedar Street

New Haven, CT 06520-8031