Departments & Organizations
Emily's overall research interests are to understand mechanisms of immune dysregulation during aging and how this contributes to chronic inflammatory diseases. Her interest in aging research began in the Nikolich-Zugich lab at the University of Arizona where she received her PhD studying how defects in T cell metabolism impact immune responses against infection during aging. Her postdoctoral research focuses on endogenous regulation of inflammation by ketone bodies - alternative metabolic fuels that are induced during fasting and caloric restriction. Emily has recently discovered that diet-induced elevations in the ketone body beta-hydroxybutyrate can reduce systemic inflammation and joint swelling in rats during acute gouty flares. She is currently extending these findings into different disease models and developing tools to test the role of ketone bodies on various immune cell subsets. Her ultimate goal is to understand mechanisms of immune-metabolic interactions that dampen inflammation to promote health and longevity.