Ann M Haberman, PhD

Associate Professor Term; Director, In Vivo Imaging Facility; Director, Flow Cytometry Facility

Research Interests

Antibody Formation; Immunity, Cellular; Lymphocyte Activation; Lymphoid Tissue; Lymphoma, Follicular; Lymphoma, B-Cell; Germinal Center; Dendritic Cells, Follicular; Immunological Synapses; Immune System Processes

Public Health Interests

Immune functions

Research Organizations

Immunobiology: FACS Facility | HTI

Faculty Research

Rheumatic Diseases Research Core

Yale Cancer Center: Cancer Immunology

Office of Cooperative Research

Research Summary

I am interested in understanding the factors that influence the proliferation, migration and differentiation of germinal center B lymphocytes. A particular interest of mine is the behavior of activated B cells and their interaction with other cell types within the context of tissue architecture. I use a combination of histology, flow cytometry and intravital multiphoton microscopy to study the factors that regulate B cell subset activation and their movements in vivo. A related area of interest includes the cellular interactions of B cell lymphomas with other cell types within lymphoma microenvironments that may influence lymphoma resistance to therapeutic treatments.

Extensive Research Description

My research has focused on the cellular and molecular interactions regulating the form and function of an inducible lymphoid tissue structure called germinal centers. Germinal centers (GC) develop in the center of B cell follicles in spleen and lymph nodes about one week after initial immunization. GCs are sites of extreme metabolism, with very high proliferation and death rates, and evolve over time to form structures with phenotypically distinct zones. GC development requires intricate interactions of B cells with multiple other cell types to achieve both the affinity maturation of immunoglobulin and the generation of memory B cells that are key to long-term immune protection.

Several lymphoma subtypes derive from germinal centers, including diffuse large B cell lymphomas, follicular lymphomas and angioImmunoblastic T cell lymphomas. The regional composition of other cell types can vary tremendously and can include CD4+ T cell subsets, dendritic cells and activated macrophages. Defining the impact of interactions with other adjacent cell types will be an essential component of advances in this field. My current research aims to tease apart the role that each may play in the cascade of events regulating the pathological variants of germinal centers.

Selected Publications

Full List of PubMed Publications

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Contact Info

Ann M Haberman, PhD
Lab Location
The Anlyan Center
300 Cedar Street, Ste S530

New Haven, CT 06519
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Office Location
The Anlyan Center
300 Cedar Street, Ste Room S541 B

New Haven, CT 06519
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Mailing Addresses
PO Box 208011
300 Cedar Street

New Haven, CT 06510-8011
1 Gilbert St
New Haven, CT 06519