Ralf M Leonhardt, PhD

Associate Research Scientist in Immunobiology

Research Summary

1.) Mechanism of amyloid formation by the protein PMEL in melanosomes

2.) Melanosome biogenesis

3.) Unconventional antigen presentation in tumors

4.) Antigen presentation via the non-classical MHC molecule CD1d

5.) Assembly and function of the peptide-loading complex

6.) Innate immunity against Chlamydia trachomatis

Selected Publications

Full List of PubMed Publications

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Contact Info

Ralf M Leonhardt, PhD
Mailing Address
Department of ImmunobiologyPO Box 208011
300 Cedar Street

New Haven, CT

Curriculum Vitae

Distribution of melanosomes and lysosomes in human melanoma cells.

Distribution of melanosomes and lysosomes in human melanoma cells. Melanosomes (red, stained for PMEL) segregate away from perinuclear lysosomes (green, stained for LAMP1) and accumulate in the cell periphery. Inset: Electron microscopy image depicting a melanosome harboring PMEL amyloid fibrils.