Research Interests

Selected publications from the last five years

• Chatterji, M., Tsai, C. L., and Schatz, D. G. (2006). Mobilization of RAG-generated signal ends by transposition and insertion in vivo. Mol Cell Biol 26, 1558-1568.
• Odegard, V. H., Kim, S. T., Anderson, S. M., Shlomchik, M. J., and Schatz, D. G. (2005). Histone modifications associated with somatic hypermutation. Immunity 23, 101-110.
• Rush, J. S., Liu, M., Odegard, V. H., Unniraman, S., and Schatz, D. G. (2005). Expression of activation-induced cytidine deaminase is regulated by cell division, providing a mechanistic basis for division-linked class switch recombination. Proc Natl Acad Sci U S A 102, 13242-13247.
• Fugmann, S. D., Rush, J. S., and Schatz, D. G. (2004). Non-redundancy of cytidine deaminases in class switch recombination. Eur J Immunol 34, 844-849.
• Rush, J. S., Fugmann, S. D., and Schatz, D. G. (2004). Staggered AID-dependent DNA double strand breaks are the predominant DNA lesions targeted to S in Ig class switch recombination. Int Immunol 16, 549-557.
• Ciubotaru, M., and Schatz, D. G. (2004). Synapsis of recombination signal sequences located in cis and DNA underwinding in V(D)J recombination. Mol Cell Biol 24, 8727-8744.
• Unniraman, S., Zhou, S., and Schatz, D. G. (2004). Identification of an AID-independent pathway for chromosomal translocations between the Igh switch region and Myc. Nat Immunol 5, 1117-1123.
• Johnson, K., Pflugh, D. L., Yu, D., Hesslein, D. G., Lin, K. I., Bothwell, A. L., Thomas-Tikhonenko, A., Schatz, D. G., and Calame, K. (2004). B cell-specific loss of histone 3 lysine 9 methylation in the V(H) locus depends on Pax5. Nat Immunol 5, 853-861.
• Horowitz, M. C., Xi, Y., Pflugh, D. L., Hesslein, D. G., Schatz, D. G., Lorenzo, J. A., and Bothwell, A. L. (2004). Pax5-deficient mice exhibit early onset osteopenia with increased osteoclast progenitors. J Immunol 173, 6583-6591.
• Schatz, D. G. (2004). Antigen receptor genes and the evolution of a recombinase. Semin Immunol 16, 245-256.
• Schatz, D. G., and Baltimore, D. (2004). Uncovering the V(D)J recombinase. Cell 116, S103-106.
• Chatterji, M., Tsai, C. L., and Schatz, D. G. (2004). New concepts in the regulation of an ancient reaction: transposition by RAG1/RAG2. Immunol Rev 200, 261-271.
• Hesslein, D. G., Pflugh, D. L., Chowdhury, D., Bothwell, A. L., Sen, R., and Schatz, D. G. (2003). Pax5 is required for recombination of transcribed, acetylated, 5' IgH V gene segments. Genes Dev 17, 37-42.
• Jung, D., Bassing, C. H., Fugmann, S. D., Cheng, H. L., Schatz, D. G., and Alt, F. W. (2003). Extrachromosomal recombination substrates recapitulate beyond 12/23 restricted V(D)J recombination in nonlymphoid cells. Immunity 18, 65-74.
• Ciubotaru, M., Ptaszek, L. M., Baker, G. A., Baker, S. N., Bright, F. V., and Schatz, D. G. (2003). RAG1-DNA binding in V(D)J recombination. Specificity and DNA-induced conformational changes revealed by fluorescence and CD spectroscopy. J Biol Chem 278, 5584-5596.
• Tsai, C. L., and Schatz, D. G. (2003). Regulation of RAG1/RAG2-mediated transposition by GTP and the C-terminal region of RAG2. EMBO J 22, 1922-1930.
• Tsai, C. L., Chatterji, M., and Schatz, D. G. (2003). DNA mismatches and GC-rich motifs target transposition by the RAG1/RAG2 transposase. Nucleic Acids Res 31, 6180-6190.
• Lee, A. I., Fugmann, S. D., Cowell, L. G., Ptaszek, L. M., Kelsoe, G., and Schatz, D. G. (2003). A functional analysis of the spacer of V(D)J recombination signal sequences. PLoS Biol 1, 56-69.
• Papavasiliou, F. N., and Schatz, D. G. (2002). Somatic hypermutation of immunoglobulin genes: Merging mechanisms for genetic diversity. Cell 109, S35-S44.
• Tsai, C. L., Drejer, A. H., and Schatz, D. G. (2002). Evidence of a critical architectural function for the RAG proteins in end processing, protection, and joining in V(D)J recombination. Genes Dev 16, 1934-1949.
• Fugmann, S. D., and Schatz, D. G. (2001). Identification of basic residues in RAG2 critical for DNA binding by the RAG1-RAG2 complex. Mol. Cell 8, 899-910.