Yale School of Medicine

Department of Immunobiology

Department of Immunobiology

Department of Immunobiology
300 Cedar Street
The Anlyan Center
P.O. Box 208011
New Haven, CT 06520

Publications

Original Research Articles 20 most recent (Peer Reviewed)

  • Ranjbaran H, Sokol SL, Gallo A, Eid RE, Ikaimov AO, D'Alessio A, Kapoor JR, Akhtar S, Howes CJ, Aslan M, Pfau S, Pober JS, Tellides G.  An inflammatory pathway of interferon-gamma production in coronary atherosclerosis.  J Immunol. 2007; 178:592-604.
  • Yamakuchi M, Kirkiles-Smith NC, Ferlito M, Cameron S, Bao C, Fox-Talbot K,Wasowska BA, Baldwin III WM, Pober JS, Lowenstein CJ.  Antibody to human leukocyte antigen triggers endothelial exocytosis.  Proc Natl Acad Sci (USA) 2007; 104:1301-1306.
  • Choy JC, Wang Y, Tellides G, Pober JS.  Induction of iNOS in bystander human T cells increases   allogeneic responses in the vasculature.  Proc Natl Acad Sci (USA) 2007; 104:1313-1318.
  • Manes TD, Shiao SL, Dengler TJ, Pober JS.  TCR signaling antagonizes rapid IP-10-mediated transendothelial migration of effector memory CD4+ T cells.  J Immunol. 2007; 178:3237-3243.  
  • Wang Y, Ahmad U, Yi T, Zhao L, Lorber MI, Pober JS, Tellides G.  Alloimmune-mediated vascular remodeling of human coronary artery grafts in immunodeficient mouse recipients is independent of pre-existing atherosclerosis.  Transplantation. 2007; 83:1501-1505.
  • Suárez Y, Fernández-Hernando C, Pober JS, Sessa WC.  Dicer dependent microRNAs regulate gene expression and functions in human endothelial cells.  Circ Res. 2007; 100:1164-1173.
  • Zhang R, Zhang H, Lin Y, Li J-H, Pober JS, Min W.  RIP1-mediated AIP1 phosphorylation at a 14-3-3-   binding site is critical for TNF-induced ASK1-JNK/p38 activation.  J Biol Chem. 2007; 282:14788-14796.
  • Shiao SL, Kirkiles-Smith NC, Shepherd BR, McNiff JM, Carr EJ, Pober JS.   Human effector memory CD4+ T cell directly recognize allogeneic endothelial cells in vitro and in vivo.  J Immunol. 2007; 179:4397-4404.
  • Wang Y, Bai Y, Qin L, Zhang P, Yi T, Teesdale SA, Zhao P, Pober JS, Tellides G.  Interferon-gamma induces human vascular smooth muscle cell proliferation and intimal expansion by PI3K-dependent mTORC1 activation. Circ Res. 2007; 101:560-569.
  • Clark P, Pober JS, Kluger MS.  Knockdown of TNFR1 by the sense strand of an ICAM-1 siRNA:   dissection of an off-target effect.  Nucl Acids Res. 2007 (in press).
  • Cuffy MC, Silverio AM, Qin L, Wang Y, Eid R, Brandacher G, Lakkis FG, Fuchs D, Pober JS, Tellides G.   Induction of Indoleamine 2, 3-Dioxygenase in vascular smooth muscle cells by interferon-gamma contributes to medial immunoprivilege.  J Immunol. 2007; 179:5246-5254.
  • Rao DA, Tracey KJ, Pober JS.  IL-1a and IL-1b are endogenous mediators linking cell injury to the  adaptive alloimmune response.  J Immunol. 2007; 179:6536-6546.
  • Suarez Y, Shepherd BR, Rao DA, Pober JS.  Alloimmunity to human endothelial cells derived from cord  blood progenitors.  J Immunol. 2007; 179:7488-7496.
  • Al-Lamki RS, Tolkovsky A, Wang J, Bradley JA, Griffin JL, Thiru S, Wang ECY, Min W, Moore P, Pober JS, Bradley JR.  TL1A both promotes and protects from renal inflammation and injury.  J Am Soc Nephrol. 2008; (in press).
  • Liu M, Kluger MS, D'Alessio A, Garcia-Cardena G, Pober JS.  Regulation of arterial-venous differences   in tumor necrosis factor responsiveness of endothelial cells by anatomic context.  Am J Path. 2008; 172: 1088-1099.
  • Bai Y, Ahmad U, Wang Y, Li JH, Choy JC, Kim RW, Kirkiles-Smith N, Maher SE, Karras JG, Bennet CF, Bothwell AL, Pober JS, Tellides G.  Interferon-gamma induces XIAP-associated factor-1 and NOXA expression and potentiates human vascular smooth muscle cell apoptosis by STAT3 activation.  J Biol Chem. 2008; 283: 6832-6842.
  • Jay SM, Shepherd BR, Bertram JP, Pober JS, Saltzman WM.  Engineering of multifunctional gels integrating highly efficient growth factor delivery with endothelial cell transplantation.  FASEB J. 2008 (in press).
  • Manes T, Pober JS.  Antigen presentation by human microvascular endothelial cells triggers ICAM-1-independent transendothelial protrusion by and fractalkine-dependent transendothelial migration of effector memory CD4+ T cells.  J Immunol. 2008 (in press).
  • Enis DR, Dunmore B, Johnson N, Pober JS, Print CG.  Anti-apoptotic activities of Bcl-2 correlate with vascular maturation and transcriptional modulation of human endothelial cells.  Endothelium. 2008 (in press).
  • Roh JD, Nelson GN, Brennan MP, Mirensky TL, Yi T, Hazlett TF, Tellides G, Sinusas AJ, Pober JSS, Saltzman WM, Kyriakides TR, Breuer CK.  Small-diameter biodegradable scaffolds for functional vascular tissue engineering in the mouse model.  Biomaterials. 2008; 29:1454-1463.