Publications

Selected Recent Publications

• Blander JM, Medzhitov, R. On regulation of phagosome maturation and antigen presentation. Nat Immunol. 2006 Oct;7(10):1029-1035.
• Stetson DB, Medzhitov, R. Type I interferons in host defense. Immunity. 2006 Sep;25(3):373-381.
• Rakoff-Nahoum S, Medzhitov, R.  Role of the innate immune system and host-commensal mutualism. Curr Top Microbiol Immunol. 2006;308:1-18.
• Liu B., Yang, Y., Dai, J. Medzhitov, R., Freudenberg, MA, Zhang, PL, Li Z. TLR4 Up-Regulation at Protein or Gene Level Is Pathogenic for Lupus-like Autoimmune Disease. J. Immunol. 2006 Nov. 15;177(10):6880-6888.
• Rakoff-Nahoum S, Medzhitov, R. Prostaglandin-secreting cells: a portable first aid kit for tissue repair. J Clin Invest. 2007 Jan;117(1):83-86.
• van  Duin D, Mohanty S, Thomas V, Ginter S, Montgomery RR, Fikrig E, Allore HG, Medzhitov, R., Shaw AC. Age-Associated Defect in Human TLR-1/2 Function. J Immunol. 2007 Jan. 15;178(2):970-975.
• Kabelitz D, Medzhitov, R. Innate immunity – cross-talk with adaptive immunity through pattern recognition and cytokines. Curr Opin Immunol. 2007 Feb;19(1):1-3
• Medzhitov, R. TLR-mediated innate immune recognition. Semin Immunol. 2007 Feb;19(1):1-2.
• Finlay BB, Medzhitov, R. Host-microbe interactions: fulfilling a niche. Cell Host Microbe. 2007 Mar 15:1(1):3-4.
• van Duin D, Allore HG, Mohanty S, Ginter S, Newman FK, Belshe RB, Medzhitov, R., Shaw AC. Prevaccine determination of the expression of costimulatory b7 molecules in activated monocytes predicts influenza vaccine responses in young and older adults. J Infect Dis. 2007 June 1;195(11):1590-1597.
• Palm NW, Medzhitov, R. Antifungal defense turns 17. Nat Immunol. 2007 Jun:8(6):549-551.
• Foster SL, Hargreaves DC, Medzhitov, R. Gene-specific control of inflammation by TLR-induced chromatin modification. Nature. 2007 June 21;447(7147):972-978.
• Rakoff-Nahoum S, Medzhitov, R. Regulation of spontaneous intestinal tumorigenesis through the adaptor protein MyD88. Science. 2007 July 6;317(5834):124-127.
• Brodsky I., Medzhitov, R. Two modes of ligand recognition by TLRs. Cell. 2007 Sep 21;130(6):979-981.
• Palm NW, Medzhitov, R. Not so fast: adaptive suppression of innate immunity. Nat Med. 2007 Oct;13(10):1142-1144.
• Medzhitov, R. Recognition of microorganisms and activation of the immune response. Nature. 2007 Oct 18:449(7164):819-826.
• Stetson DB, Medzhitov, R. T helper 17 cells get the NOD. Immunity. 2007 Oct;27(4):546-548.
• Horng T., Bezbradica JS., Medzhitov, R. NKG2D signaling is coupled to the interleukin 15 receptor signaling pathway. Nat Immunol. 2007 Dec;8(12):1345-1352.
• Sokol CL, Barton GM, Farr AG, Medzhitov, R. A mechanism for the initiation of allergen-induced T helper type 2 responses. Nat Immunol. 2008 Mar;9(3):310-318.
• Unni, AM, Bondar T, Medzhitov, R. In Intrinsic sensor of oncogenic transformation induces a signal for innate immunosurveillance. Proc Natl Acad Sci U S A. 2008 Feb 5;105(5):1686-1691.
• Kagan JC, Su T, Horng T, Chow A, Akira S, Medzhitov, R. TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta. Nat Immunol. 2008 Apr;9(4):361-368.
• Brodsky I., Medzhitov, R. Reduced secretion of YopJ by Yersinia limits in vivo cell death but enhances bacterial virulence. PLoS Pathog. 2008 May 16;4(5):e1000067.